Chloroquine Phosphate or Chloroquine Diphosphate CAS 50-63-5 China Chloroquine Phosphate or Chloroquine Diphosphate factory, Supplier, Manufacturer in China. CAS Number: 50-63-5 Characteristics: White crystalline powder. Molecular Formula: C18H32ClN3O8P2 Structure Formula: Package: 25Kgs/ Fiber...
Chloroquine Phosphate or Chloroquine Diphosphate CAS 50-63-5
China Chloroquine Phosphate or Chloroquine Diphosphate factory, Supplier, Manufacturer in China.
CAS Number: 50-63-5
Characteristics: White crystalline powder.
Molecular Formula: C18H32ClN3O8P2
Package: 25Kgs/Fiber Drum
KEY Words: Chloroquine Phosphate or Chloroquine Diphosphate
Chloroquine Phosphate can be used for the treatment of chloroquine sensitive falciparum malaria, vivax malaria and other malaria. It can also be used in the treatment of extraintestinal amebiasis, as well as anti rheumatism.
The novel coronavirus 2019-nCoV infection can be effectively inhibited with the help of Chloroquine Phosphate at the cell level, according to the study.
Chloroquine Phosphate or Chloroquine Diphosphate is white crystalline powder, odorless and bitter. The color changes with light and the aqueous solution shows acid reaction. This product is soluble in water, almost insoluble in ethanol, chloroform and ether. Melting point is 193-196 degrees, and it decomposes at the same time during melting.
Pharmacodynamics: Chloroquine Phosphate or Chloroquine Diphosphate makes the nucleus of Plasmodium broken, vacuoles appear between cells, and the malarial pigment agglomerate. It is known that this product can not kill Plasmodium directly, but it can interfere with its reproduction. Its mechanism lies in its strong binding force with nucleoprotein. It can be inserted between the two strands of DNA double helix and form a complex with DNA, thus preventing DNA replication and RNA transcription. Chloroquine can also inhibit the incorporation of phosphate into the DNA and RNA of Plasmodium and interfere with the reproduction of Plasmodium. Chloroquine Phosphate or Chloroquine Diphosphate accumulates in the infected erythrocytes, and the food vesicles and lysosomes of protozoa are the concentrated sites. The hemoglobin enzyme that digests hemoglobin is lost, and the Plasmodium can't digest the hemoglobin, which leads to the lack of amino acids necessary for the growth and development of Plasmodium and the disintegration of RNA. In addition, Chloroquine Phosphate or Chloroquine Diphosphate can interfere with fatty acids entering phospholipids and control glutamate dehydrogenase and hexokinase. Chloroquine Phosphate or Chloroquine Diphosphate mainly acts on schizonts in the red phase. After 48-72 hours, schizonts in the blood are killed. This product has no effect on the infrared phase of Plasmodium vivax, so it can't cure it. Falciparum malaria can be cured. Chloroquine Phosphate or Chloroquine Diphosphate also has no direct effect on gametophyte, so it can not be used for etiology prevention and interruption of transmission.
Note: forbidden for pregnant women
Chloroquine Phosphate is easy to cause allergic dermatitis when used together with some special drugs.
If used combined with chlorpromazine, it is easy to aggravate liver damage.
Chloroquine Phosphate has a direct inhibitory effect on neuromuscular junction, and streptomycin can aggravate this side effect.
When used with heparin or penicillamine, it can increase the chance of bleeding.
If used together with primaquine, it might cure Plasmodium vivax.
1. Because Chloroquine Phosphate can change the pH value of endocytosomes, it has a significant inhibitory effect on the virus infection through endocytosis.
2. Chloroquine Diphosphate can affect viral replication by inhibiting viral gene expression. In vitro and in vivo experiments showed that chloroquine could change glycosylation mode of gp120 envelope and inhibit HIV replication in CD4 + T cells.
3. Chloroquine Phosphate or Chloroquine Diphosphate, as a good autophagy inhibitor, can interfere with virus infection and replication by influencing autophagy.
1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, phosphate (1:2); 7-Chloro-4-[4-(diethylamino)-1-methylbutylamino]quinoline Diphosphate; N4-(7-Chloro-4-quinolyl)-N1,N1-diethyl-1,4-pentanediamine Diphosphate;
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